Table 1. Impact of mixing patterns on probability of elimination.
Scenario | Probability of elimination (range 0–1)a | ||
---|---|---|---|
Random MDA participationb | Semi-systematic MDA participationb | Fully systematic MDA participationb | |
40% pre-control mf prevalence in age 5+ and 5 rounds of annual MDA at 65% coverage | |||
k = 3.5 (one fly population) | 0.98 | 0.97 | 0.85 |
k = 3.5, fH = 0.50, mixt = 0.8 | 0.67 | 0.60 | 0.52 |
k = 3.5, fH = 0.25, mixt = 0.8 | 0.02 | 0.03 | 0.01 |
k = 3.5, fH = 0.10, mixt = 0.8 | 0.01 | 0.00 | 0.00 |
k = 1.0 (one fly population) | 0.42 | 0.33 | 0.27 |
50% pre-control mf prevalence in age 5+ and 7 rounds of annual MDA at 65% coverage | |||
k = 3.5 (one fly population) | 0.99 | 1.00 | 0.93 |
k = 3.5, fH = 0.50, mixt = 0.8 | 0.65 | 0.51 | 0.25 |
k = 3.5, fH = 0.25, mixt = 0.8 | 0.04 | 0.03 | 0.00 |
k = 3.5, fH = 0.10, mixt = 0.8 | 0.02 | 0.02 | 0.01 |
k = 1.0 (one fly population) | 0.28 | 0.32 | 0.14 |
60% pre-control mf prevalence in age 5+ and 11 rounds of annual MDA at 65% coverage | |||
k = 3.5 (one fly population) | 1.00 | 1.00 | 0.98 |
k = 3.5, fH = 0.50, mixt = 0.8 | 0.99 | 0.86 | 0.38 |
k = 3.5, fH = 0.25, mixt = 0.8 | 0.54 | 0.25 | 0.06 |
k = 3.5, fH = 0.10, mixt = 0.8 | 0.26 | 0.21 | 0.08 |
k = 1.0 (one fly population) | 0.57 | 0.39 | 0.06 |
a Elimination is defined as zero mf prevalence 50 years after stopping MDA; probability of elimination is defined as the fraction of 200 repeated simulations that meet aforementioned criterion.
b Random MDA participation means that every eligible individual is just as likely to participate; fully systematic participation means that always the same eligible persons participate; semi-systematic participation is a mix of random and fully systematic participation.