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. 2018 Oct 8;12(10):e0006624. doi: 10.1371/journal.pntd.0006624

Table 1. Impact of mixing patterns on probability of elimination.

Scenario Probability of elimination (range 0–1)a
Random MDA participationb Semi-systematic MDA participationb Fully systematic MDA participationb
40% pre-control mf prevalence in age 5+ and 5 rounds of annual MDA at 65% coverage
k = 3.5 (one fly population) 0.98 0.97 0.85
k = 3.5, fH = 0.50, mixt = 0.8 0.67 0.60 0.52
k = 3.5, fH = 0.25, mixt = 0.8 0.02 0.03 0.01
k = 3.5, fH = 0.10, mixt = 0.8 0.01 0.00 0.00
k = 1.0 (one fly population) 0.42 0.33 0.27
50% pre-control mf prevalence in age 5+ and 7 rounds of annual MDA at 65% coverage
k = 3.5 (one fly population) 0.99 1.00 0.93
k = 3.5, fH = 0.50, mixt = 0.8 0.65 0.51 0.25
k = 3.5, fH = 0.25, mixt = 0.8 0.04 0.03 0.00
k = 3.5, fH = 0.10, mixt = 0.8 0.02 0.02 0.01
k = 1.0 (one fly population) 0.28 0.32 0.14
60% pre-control mf prevalence in age 5+ and 11 rounds of annual MDA at 65% coverage
k = 3.5 (one fly population) 1.00 1.00 0.98
k = 3.5, fH = 0.50, mixt = 0.8 0.99 0.86 0.38
k = 3.5, fH = 0.25, mixt = 0.8 0.54 0.25 0.06
k = 3.5, fH = 0.10, mixt = 0.8 0.26 0.21 0.08
k = 1.0 (one fly population) 0.57 0.39 0.06

a Elimination is defined as zero mf prevalence 50 years after stopping MDA; probability of elimination is defined as the fraction of 200 repeated simulations that meet aforementioned criterion.

b Random MDA participation means that every eligible individual is just as likely to participate; fully systematic participation means that always the same eligible persons participate; semi-systematic participation is a mix of random and fully systematic participation.