Table 2. Functional modules for hypertrophy signaling network.

Functional species modules identified by k-means clustering of the predicted activity change in each species activity from transgenic overexpression of 33 individual species.

Module	Members
Extracellular signaling molecules and receptors	TNFα, TNFR, NIK, ISO, βAR, Gsα, AC, cAMP, PKA, NE, PE, αAR, ET1, ET1R, IGF1, IGF1R, EGF, EGFR, PLCγ, AngII, AT1R, NRG1, ERBB, TGFβ, TGFR, IL6, IL6R, FGF, FGFR, CT1, LIF, gp130LIFR, JAK, STAT, SHP2, stretch, Integrins, FAK, BNPi, ANPi, GCA
G protein coupling	Gαq/11, Gβγ, PLCβ, IP3, DAG
Inhibitory and inhibited species	HDAC, GSK3β, foxo, IκB, SERCA, αMHC
Ras/MAP Kinase	Ras, Raf1A, MEKK1, Rac1, MAP3K11, MAP3K4, MAP3K23, MEK36, MEK4, MEK7, p38, MAPKAPK, JNK, ATF2, ELK1, RhoA, SRF, MEK5, ERK5, MEF2
Calcium/NFAT	Calcium, calmodulin, calcineurin, CaMK, PKC, TAK1, PKD,,NFAT
Akt	PI3K, PDK1, Akt, mTor, eIF4E, IKK, p70s6k, eIF2B, CREB, NOS, sGC, cGMP, PKG1
ERK1	Raf1, NFκB, MEK12, ERK12, MSK1, GATA4, cFos, cJun
Upregulated outputs	Cell area, heart weight/body weight, βMHC, BNP, ANP, sACT