Figure 6.

Anabasum alters vascular hyperemia at the site of UVkEc triggered self‐resolving dermal inflammation. Healthy male volunteers were randomized to receive by oral route either placebo, 5 mg anabasum, 20 mg anabasum, twice daily, or 15 mg prednisolone once daily for 4 days. On the fourth day, acute inflammation was triggered by intradermal injection of 1.5 × 10⁷ UV‐killed E. coli (UVkEc) suspended in 100 μL of saline in both forearms. Vascular hyperemia at the injection site was assessed at specified intervals by a laser Doppler imager. The comparison of vascular hyperemia (mean ± SD) between the four treatment groups (a), the representative Doppler flux images at 24 h and 48 h in the four treatment groups (b) and the neutrophil count at 24 h and 48 h in the placebo and 20 mg anabasum (c) are shown. Data expressed as individual values with mean ± SD. n = 5/group.