Table 1.
Baseline characteristics
| Characteristics | Patients with EF ≤40% (N = 812) |
|---|---|
| Sex—n (%) | |
| Male | 563 (69) |
| Female | 249 (31) |
| Age—years, mean (SD) | 75 (12) |
| Systolic blood pressure—mm Hg, mean (SD) | 126 (19) |
| Diastolic blood pressure—mm Hg, mean (SD) | 74 (11) |
| Ejection fraction—%, mean (SD) | 33 (7) |
| Heart rate—beats/min, mean (SD) | 75 (15) |
| Body mass index—kg/m2, mean (SD) | 27 (5) |
| Laboratory values | |
| NT‐proBNP—pg/mL, median (IQR) | 1224 (432‐2899) |
| Potassium—mmol/L, mean (SD) | 4.4 (1.5) |
| Serum creatinine—μmol/La, mean (SD) | 108 (60) |
| Creatinine clearance—mL/min, mean (SD) | 68 (33) |
| Creatinine clearance—n (%) | |
| ≥90 mL/min | 182 (22) |
| 60‐89 mL/min | 235 (29) |
| 30‐59 mL/min | 305 (38) |
| 15‐29 mL/min | 76 (9) |
| <15 mL/min | 6 (1) |
| Medical history—n (%) | |
| Atrial fibrillation | 387 (48) |
| Diabetes | 185 (23) |
| Hypertension | 554 (68) |
| Coronary diseaseb | 386 (48) |
| Medications and devices—n (%) | |
| ACE inhibitor | 383 (47) |
| ARB | 353 (43) |
| Beta‐blocker | 730 (90) |
| Diuretics | 497 (61) |
| Digitalis | 95 (12) |
| Implantable cardioverter‐defibrillatorc | 108 (13) |
| Cardiac resynchronization therapyc | 105 (13) |
ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; IQR, interquartile range; NT‐proBNP, N‐terminal pro–B‐type natriuretic peptide; SD, standard deviation.
a
To convert the values for creatinine to mg/dL, divide by 88.4.
b
Coronary artery disease defined as either previous myocardial infarction or documented stenosis of at least 50%.
c
Including patients with Cardiac Resynchronization Therapy Defibrillator (CRT‐D).