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Synthesis of “right arm” cyclopeptide 6. Reagents and conditions: [a] 1 % TFA/ CH2Cl2, 10×10 min; [b] PyBOP® (1.2 equiv), DIPEA (2.0 equiv), DMF/CH2Cl2 (1:1), 0.5 mm linear peptide, r.t., 30 min, 48 % overall; [c] 96 % TFA, 2 % TIS, 2 % H2O, r.t., 3 h, 96 %; [d] NaIO4 (10 equiv), H2O, r.t., 40 min, 71 %.
