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. 2018 Apr 27;68(3):1057–1069. doi: 10.1002/hep.29888

Figure 3.

Figure 3

Myrcludex B treatment further raises plasma bile salt concentrations and reduces intracellular bile salt accumulation during cholestasis. Conjugated (A) and unconjugated (B) BS concentrations in DDC‐fed mice and Atp8b1‐G308V mutant mice. (C) mRNA expression levels of Shp and Cyp7a1 compared to untreated non‐cholestatic mice, and plasma levels of C4 in DDC‐fed mice. (D) mRNA expression level of Fgf15 in the terminal ileum of DDC‐fed mice compared to untreated non‐cholestatic mice. (E) mRNA expression levels of Shp and Cyp7a1 compared to untreated non‐cholestatic mice, and plasma levels of C4 in Atp8b1‐G308V mutant mice. (F) mRNA expression level of Fgf15 in the terminal ileum of Atp8b1‐G308V mutant mice compared to untreated non‐cholestatic mice. Asterisk indicates significant change compared to the cholestatic mouse group, hashtag indicates significant change compared to the non‐cholestatic mouse group (n=8‐14 mice/group).