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. 2018 Jan 11;109(8):e23098. doi: 10.1002/bip.23098

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© 2018 The Authors Biopolymers Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Energetic Impact of Introducing a Second AP‐Site within CCC/GFG at the 5′‐staggered (FCC/GFG), 3′‐staggered (CCF/GFG), and Central (CFC/GFG) Orientations, respectively. Effect of introducing two abasic sites within the canonical undamaged duplex (Left Panel) or a second abasic site within a single AP‐site duplex (Right Panel). Differential data are derived by subtracting dissocition parameters from the corresponding reference (CCC/GGG) and single AP‐site (CCC/GFG) duplexes. The bistrand abasic site duplexes are thermodynamically destabilized relative to the undamaged parent tridecamer with CCF/GFG > FCC/GFG ∼ CFC/GFG (Left Panel). Further destabilization is observed for the 3′staggered bistrand duplex relative to CCC/GFG with CCF/GFG > FCC/GFG ∼ CFC/GFG (Right Panel)