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. 2018 Oct 1;24(4):656–668. doi: 10.5056/jnm18037

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© 2018 The Korean Society of Neurogastroenterology and Motility

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overexpression of cannabinoid receptor 1 (CNR1) and serotonin transporter (SERT) partially rescued the inhibitory effects of microR-NA-200a (miR-200a) on diarrhea-predominant irritable bowel syndrome rat colonic epithelial cells (CECs). (A) Western blots showed that the expression of CNR1/SERT was significantly upregulated in CECs transfected with pcDNA3.1-CNR1/SERT but significantly downregulated in CECs transfected with miR-200a. In addition, a significant increase in CNR1/SERT was detected in CECs transfected with pcDNA3.1-CNR1/ SERT alone compared to CECs co-transfected with pcDNA3.1-CNR1/SERT and miR-200a. (B) Quantitative RT-PCR shows similar results to western blot (P < 0.05, ANOVA and least significant difference).