Table 4.
Relative Expression (2−ΔCt) of Toll-like Receptors, Cytokines, and Chemokines, Among Different Subtypes of Patients With Irritable Bowel Syndrome and Controls
| Target gene | Controls (n = 25) median (range) |
IBS-C (n = 20) median (range) |
IBS-D (n = 20) median (range) |
IBS-U (n = 7) median (range) |
P-valuea |
|---|---|---|---|---|---|
| TLR-4b,c | 0.03 (0.0–13.1) | 0.07 (0.0–5.1) | 0.40 (0.0–26.6) | 0.24 (0.0–2.0) | 0.009 |
| TLR-5b,c | 0.03 (0.0–1.5) | 0.45 (0.0–4.9) | 2.13 (0.0–6.5) | 2.95 (0.4–4.7) | < 0.001 |
| IL-6b | 0.10 (0.0–2.8) | 0.45 (0.0–5.0) | 1.10 (0.0–2.1) | 0.90 (0.0–1.7) | 0.016 |
| IL-10b,c | 1.00 (0.0–8.1) | 2.25 (0.0–17.2) | 0.05 (0.0–8.8) | 0.00 (0.0–3.0) | 0.003 |
| CXCL-11b | 0.10 (0.0–15.4) | 1.35 (0.0–34.7) | 3.60 (0.0–57.9) | 29.00 (0.4–98.8) | < 0.001 |
| CXCR-3b,c,d | 0.00 (0.0–25.2) | 0.80 (0.0–8.3) | 4.40 (0.0–24.8) | 1.00 (0.3–12.0) | < 0.001 |
a
Kruskal Wallis test with post hoc analysis. P < 0.05 was considered significant.
b
P < 0.017 between patients with IBS-D and controls.
c
P < 0.017 between IBS-C and IBS-D.
d
Bonferroni corrected P-value < 0.017 was considered significant for subgroup analysis.