Table 1.
Demographics of Gastroesophageal Reflux Disease Patients Using a Universal Explorys Dataset
| Year | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | Trend test | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Total number of GERD | 179 300 | 241 470 | 299 190 | 375 110 | 487 170 | 602 110 | 807 900 | 957 650 | 1 113 910 | 1 113 160 | 1 032 140 | z-value | P-value |
| Age (yr, n [%]) | |||||||||||||
| 15–19 | 1200 (0.7) | 1540 (0.6) | 1920 (0.6) | 2570 (0.7) | 2900 (0.6) | 3610 (0.6) | 4920 (0.6) | 6340 (0.7) | 8440 (0.8) | 9050 (0.8) | 9170 (0.9) | 25.07 | < 0.001 |
| 20–29 | 3270 (1.8) | 4159 (1.7) | 6450 (2.2) | 9010 (2.4) | 12 510 (2.6) | 17 710 (2.9) | 25 460 (3.2) | 33 030 (3.5) | 42 400 (3.8) | 44 340 (4.0) | 43 280 (4.2) | 106.04 | < 0.001 |
| 30–39 | 7820 (4.4) | 11120 (4.6) | 15 580 (5.2) | 20 760 (5.5) | 28 260 (5.8) | 37 300 (6.2) | 52 160 (6.5) | 64 340 (6.7) | 78 950 (7.1) | 81 440 (7.3) | 78 480 (7.6) | 91.31 | < 0.001 |
| 40–49 | 15 810 (8.8) | 21 600 (8.9) | 28 300 (9.5) | 36 410 (9.7) | 47 980 (9.9) | 61 030 (10.1) | 84 370 (10.4) | 101 980 (10.7) | 123 330 (11.1) | 125 370 (11.3) | 119 800 (11.6) | 66.70 | < 0.001 |
| 50–59 | 28 670 (16.0) | 39 180 (16.2) | 49 310 (16.5) | 62 040 (16.5) | 81 670 (16.8) | 102 210 (17.0) | 139 460 (17.3) | 167 670 (17.5) | 199 430 (17.9) | 202 000 (18.2) | 190 600 (18.5) | 49.13 | < 0.001 |
| 60–69 | 38 990 (21.8) | 52 580 (21.8) | 64 030 (21.4) | 80 870 (21.6) | 104 850 (21.5) | 128 990 (21.4) | 174 020 (21.5) | 207 490 (21.7) | 243 070 (21.8) | 247 180 (22.2) | 232 140 (22.5) | 17.72 | < 0.001 |
| ≥70 | 72 870 (40.6) | 96 430 (39.9) | 115 620 (38.6) | 141 540 (37.7) | 182 490 (37.5) | 219 110 (36.4) | 285 850 (35.4) | 326 930 (34.1) | 362 370 (32.5) | 348 880 (31.3) | 310 040 (30.0) | −168.81 | < 0.001 |
| Sex (male, n [%]) | 71 310 (39.8) | 96 210 (39.8) | 119 700 (40.0) | 148 100 (39.5) | 190 460 (39.1) | 235 780 (39.2) | 317 490 (39.3) | 377 940 (39.5) | 441 900 (39.7) | 441 050 (39.6) | 409 560 (39.7) | ||
| Race (n [%]) | |||||||||||||
| Caucasian | 136 420 (76.1) | 186 920 (77.4) | 231 290 (77.3) | 293 760 (78.3) | 384 950 (79.0) | 482 130 (80.1) | 648 510 (80.3) | 770 180 (80.4) | 893 210 (80.1) | 897 940 (80.7) | 829 430 (80.4) | ||
| African American | 29 510 (16.5) | 34 690 (14.4) | 41 990 (14.0) | 50 660 (13.5) | 65 870 (13.5) | 79 130 (13.1) | 104 780 (13.0) | 115 120 (12.0) | 133 320 (12.0) | 132 280 (11.9) | 122 840 (11.9) | ||
| Hispanic/Latino | 1110 (0.6) | 1700 (0.7) | 2390 (0.8) | 3260 (0.9) | 4460 (0.9) | 5500 (0.9) | 6850 (0.8) | 8200 (0.86) | 10 330 (0.9) | 11 270 (1.0) | 11 380 (1.1) | ||
| Asian | 1940 (1.1) | 2590 (1.1) | 3130 (1.0) | 4310 (1.1) | 5620 (1.2) | 7260 (1.2) | 9620 (1.2) | 14 390 (1.5) | 16 260 (1.5) | 15 900 (1.4) | 14 850 (1.4) | ||
| Native American or Alaskan Native | - | - | - | - | - | - | - | - | - | - | - | ||
| Asian/Pacific Islander | - | - | - | - | - | - | - | - | - | - | - | ||
| Unknown Race | 26 670 (14.9) | 40 640 (16.8) | 50 970 (17.0) | 60 030 (16.0) | 76 840 (15.8) | 92 900 (15.4) | 115 860 (14.3) | 127 790 (13.3) | 140 100 (12.6) | 140 480 (12.6) | 133 180 (12.9) | ||
| Other | 5250 (2.9) | 7120 (2.9) | 9490 (3.2) | 11450 (3.1) | 14620 (3.0) | 18440 (3.1) | 25930 (3.2) | 34230 (3.6) | 45780 (4.1) | 47520 (4.2) | 45930 (4.4) | ||
| BMI (n [%]) | |||||||||||||
| Severe obesity (BMI ≧ 40 kg/m2) | 8350 (30.1) | 12 080 (30.1) | 16 430 (30.6) | 21 910 (31.1) | 30 370 (31.1) | 39 680 (31.1) | 57 130 (31.1) | 69 980 (31.2) | 84 130 (31.0) | 87 470 (30.7) | 83 180 (31.0) | ||
| Obesity (30 ≦ BMI < 40 kg/m2) | 12 230 (44.1) | 17 850 (44.5) | 23 650 (44.0) | 30 970 (43.9) | 42 970 (44.0) | 56 670 (44.4) | 83 970 (45.8) | 103 420 (46.2) | 126 710 (46.6) | 134 850 (47.4) | 129 360 (48.3) | ||
| Overweight (25 ≦ BMI < 30 kg/m2) | 2310 (8.3) | 3400 (8.5) | 4720 (8.8) | 6310 (9.0) | 8440 (8.6) | 10 900 (8.5) | 14 860 (8.1) | 17 820 (8.0) | 22 820 (8.4) | 27 800 (9.8) | 33 390 (12.5) | ||
| Normal (20 ≦ BMI < 25 kg/m2) | 1450 (5.2) | 1900 (4.7) | 2530 (4.7) | 3270 (4.6) | 4870 (5.0) | 6330 (5.0) | 8370 (4.6) | 10 190 (4.5) | 12 670 (4.7) | 15 380 (5.4) | 18 370 (6.9) | ||
| Underweight (BMI < 20 kg/m2) | 530 (1.9) | 740 (1.8) | 950 (1.8) | 1260 (1.8) | 1770 (1.8) | 2410 (1.9) | 3340 (1.8) | 4190 (1.9) | 5690 (2.1) | 7670 (2.7) | 10 480 (3.9) | ||
| PPI usage (n) | |||||||||||||
| Total | 117 470 | 165 810 | 210 560 | 265 410 | 343 550 | 431 220 | 584 000 | 706 240 | 828 400 | 831 990 | 761 910 | ||
| 15–19 yr | 580 | 770 | 1020 | 1330 | 1460 | 1860 | 2560 | 3470 | 4680 | 5000 | 5060 | 19.75 | < 0.001 |
| 20–29 yr | 1650 | 2440 | 3640 | 4880 | 6650 | 9820 | 14 590 | 19 470 | 25 440 | 27 240 | 26 090 | 85.17 | < 0.001 |
| 30–39 yr | 4160 | 6370 | 9310 | 12 520 | 16 750 | 23 030 | 33 120 | 42 360 | 53 290 | 56 190 | 53 680 | 90.29 | < 0.001 |
| 40–49 yr | 9680 | 13 880 | 19 030 | 24 700 | 32 260 | 42 280 | 59 510 | 73 970 | 91 120 | 93 760 | 88 530 | 69.13 | < 0.001 |
| 50–59 yr | 18 960 | 27 290 | 35 260 | 44 810 | 58 890 | 75 060 | 102 450 | 126 490 | 152 300 | 155 030 | 144 190 | 45.36 | < 0.001 |
| 60–69 yr | 27 230 | 38 270 | 47 480 | 60 760 | 78 420 | 97 790 | 132 380 | 160 230 | 189 290 | 192 840 | 178 840 | 8.45 | < 0.001 |
| ≥70 yr | 50 750 | 70 120 | 86 480 | 106 110 | 136 680 | 166 030 | 219 040 | 256 440 | 285 750 | 275 790 | 242 560 | −150.21 | < 0.001 |
GERD, gastroesophageal reflux disease; BMI, body mass index; PPI, proton pump inhibitor.