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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: J Org Chem. 2018 May 29;83(12):6307–6314. doi: 10.1021/acs.joc.8b00169

Scheme 1.

Scheme 1

Core chlorin platform in green is modified by successive click chemistries to append PEG groups that modulate solubility, and conjugate biomolecules for targeting and tracking. The chelated metal ions modulate the photophysics.