Table 2.
Oral administration of naringenin inhibited the formation of TBARS and hydroperoxides, and increased the activities of SOD, CAT, GPx, GST, and GSH in livers of STZ-treated mice
| Groups | TBARS(mM/100 g tissue) | Hydroperoxides (mM/100 g tissue) | SOD | CAT | GPx | GST | GSH (mg/100g tissue) |
|---|---|---|---|---|---|---|---|
| Control | 0.72±0.07# | 67.33±7.6# | 9.49±0.4# | 61.37±1.7# | 10.63±0.4# | 7.15±0.2# | 24.13±1.0# |
| NAR control (100 mg/kg) | 0.70±0.05 | 65.29±5.8 | 9.52±0.4 | 62.36±1.8 | 10.66±0.5 | 7.21±0.4 | 24.66±1.1 |
| STZ alone | 1.63±0.18 | 98.13±11.9 | 3.92±0.2 | 45.81±5.0 | 5.94±0.2 | 3.16±0.2 | 15.24±0.3 |
| STZ+NAR (50 mg/kg) | 1.20±0.10# | 79.83±10.1# | 6.06±0.1# | 53.72±5.8# | 7.73±0.2# | 5.11±0.4# | 19.43±0.9# |
| STZ+NAR (100 mg/kg) | 0.87±0.15# | 66.97±8.8# | 7.39±0.4# | 58.38±5.3# | 8.9±0.6# | 6.01±0.5# | 22.15±1.7# |
| STZ+GLC (600 μg/kg) | 0.78±0.16# | 66.71±7.7# | 8.03±0.3# | 60.49±5.8# | 9.46±0.3# | 6.75±0.3# | 23.71±1.6# |
Values are given as means ± SEMs for groups of six mice in each. One-way ANOVA followed by Tukey’s post hoc test. Control mice, STZ + naringenin (NAR, 50 and 100 mg/kg) and STZ+GLC (600 µg/kg) -treated mice were compared with STZ-treated mice; P<0.05. Activity is expressed as 50% of inhibition of NBT/min for SOD; µM of hydrogen peroxide consumed/min/mg of protein for catalase; µM of glutathione oxidized/min/mg of protein for GPx; and μM of CDNB conjugate formed/min/mg protein for GST.