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. Author manuscript; available in PMC: 2019 Sep 20.
Published in final edited form as: Cell. 2018 Aug 30;175(1):224–238.e15. doi: 10.1016/j.cell.2018.08.005

Figure 1. Nearly all disease-associated short tandem repeats (daSTRs) susceptible to pathologic instability are positioned at chromatin domain boundaries in human embryonic stem cells.

Figure 1.

(A-B) Heatmaps of 40 kilobase binned Hi-C data in human embryonic stem cells. (A) daSTR loci co-localized with TAD (blue) and (B) subTAD (yellow) boundaries. Genes (green) containing the daSTR (red) are shown in the tracks below heatmaps. Domain boundaries at the daSTR are demarcated with a black arrow. (C) Stacked bar plot showing number of daSTRs located at TAD, subTAD, or qualitative domain boundaries in human embryonic stem cells. TAD/subTAD calls were determined using the DI-HMM and 3DNetMod methods as detailed in Methods. See also Figures S1-S3.