Table 4.

Reasons for causal effect preferences and knowledge of analytic methods by effect estimates in their most recent pragmatic randomized trial among surveyed investigators

	Planned effect estimates in current or most recent pragmatic trial
	Intention-to-treat as primary analysis (n=12)	Intention-to-treat as secondary analysis (n=3)	Per-protocol as secondary analysis (n=7)
Prefer this effect in an effectiveness (superiority) trial because:
The causal question it answers	9	3	4
Always estimate this effect	6	1	0
Ability to estimate without bias	5	2	0
Ease of communicating to others	2	1	1
Ease of estimation	2	1	0
Trial-specific factors	2	0	0
Other	--	--	2
Familiarity with using post-randomization factors to adjust for loss to follow-up
Not familiar	3	1	1
Somewhat familiar	8	2	5
Very familiar	1	0	1
Familiarity with using post-randomization factors to adjust for adherence
Not familiar	7	3	3
Somewhat familiar	3	0	3
Very familiar	1	0	1