Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Exp Hematol. 2018 Jul 19;66:42–49. doi: 10.1016/j.exphem.2018.07.004

Table 4.

Multiple linear regression model evaluating the effects of GCH1 SNPs on chronic pain in SCD

Additive
 Dominant
 Recessive
B (95% CI)a p-value B (95% CI)a p-value B (95% CI)a p-value
rs752688 1.51 (−3.13, 6.15) 0.521 1.81 (−3.80, 7.41) 0.524 1.95 (−10.58, 14.48) 0.758
rs3783641 1.65 (−2.20, 5.50) 0.397 2.57 (−3.11, 8.24) 0.372 1.59 (−5.49, 8.67) 0.657
rs4411417 0.47 (−3.84, 4.78) 0.829 0.96 (−4.32, 6.24) 0.719 −1.16 (−12.51, 10.18) 0.839
rs8007267 −3.76 (−7.28, −0.24) 0.037 −5.61 (−10.37, −0.85) 0.021 −3.03 (−10.42, 4.36) 0.419
rs10483639 3.23 (−0.27, 6.72) 0.070 3.56 (−1.33, 8.45) 0.152 5.46 (−1.48, 12.40) 0.122
a

Unstandardized regression coefficient and 95% CI. Regression models are adjusted for age, sex, and sickle cell type.