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. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Exp Hematol. 2018 Jul 19;66:42–49. doi: 10.1016/j.exphem.2018.07.004

Table 5.

Negative binomial regression model evaluating the effect of GCH1 SNPs on acute crisis pain

	Additive		Dominant		Recessive
	IRR (95% CI)^a	p-value	IRR (95% CI)^a	p-value	IRR (95% CI)^a	p-value

rs752688	1.21 (0.88, 1.71)	0.273	1.15 (0.75, 1.78)	0.516	1.99 (0.88, 5.33)	0.127
rs3783641	1.37 (1.05, 1.81)	0.024	1.36 (0.90, 2.06)	0.144	1.81 (1.11, 3.05)	0.018
rs4411417	1.08 (0.79, 1.51)	0.641	1.02 (0.67, 1.55)	0.938	1.54 (0.70, 3.90)	0.317
rs8007267	0.78 (0.60, 1.03)	0.078	0.76 (0.53, 1.10)	0.149	0.66 (0.37, 1.19)	0.151
rs10483639	1.02 (0.79, 1.33)	0.859	0.97 (0.67, 1.40)	0.855	1.17 (0.71, 2.01)	0.550

^a

IRR and 95% CI.

Regression models are adjusted for age, sex, and sickle cell type.