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. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Exp Hematol. 2018 Jul 19;66:42–49. doi: 10.1016/j.exphem.2018.07.004

Table 6.

Association tests evaluating the effect of GCH1 SNPs rs8007267 and rs3783641 on CPI and utilization in SS type (SCD-SS and SCD-Sβ°) cohort

	Additive		Dominant		Recessive
	B (95% CI)^a	p-value	B (95% CI)^a	p-value	B (95% CI)^a	p-value

rs3783641	1.65 (−2.48, 5.77)	0.430	3.37 (−2.62, 9.35)	0.267	0.20 (−7.63, 8.02)	0.960
rs8007267	−4.26 (−8.27, −0.25)	0.037	−6.43 (−11.67, −1.18)	0.017	−2.50 (−11.14, 6.14)	0.567
	IRR (95% CI)^b	p–value	IRR (95% CI)^a	p–value	IRR (95% CI)^a	p–value
rs3783641	1.44 (1.11, 1.89)	0.012	1.53 (1.01, 2.32)	0.054	1.97 (1.19, 3.36)	0.013
rs8007267	0.76 (0.57, 1.02)	0.076	0.69 (0.47, 1.02)	0.065	0.75 (0.40, 1.49)	0.385

^a

Unstandardized regression coefficient and 95% confidence interval.

^b

IRR and 95% CI.

Regression models are adjusted for age and sex.