Table 1.
Summary of TRPC channel subtype expression and their cell-type dependent effects
| CELL TYPE | EXPRESSION LEVEL OF TRPC CHANNEL | EFFECT ON CELL | STIMULATOR | PHYSIOLOGICAL FUNCTION | REFERENCE |
|---|---|---|---|---|---|
| GnRH neurons (m) | 4>1>5 | Increases excitability | Kisspeptin | Reproduction | Zhang 2008, 2013; Bosch 2013 |
| POMC neurons (m, g) | 5>1>4>7>6 (m) | Increases excitability | Leptin, insulin, | Energy homeostasis; anorexigenic | Qiu 2010 (m); Qiu 2014 (g); Gao 2017 (m) |
| ARH Kiss1 neurons (m,g) | 5 (m) | Increases excitability | Senktide, insulin | Reproduction | Qiu (new data, m); Qiu 2014 |
| Hypocretin/Orexin neurons (r) | 4,5>7>1>3 | Increases excitability | Unknown, but controls excitability | Arousal | Cvetkovic-Lopes 2010 |
| Vasopressin neurons (r) | 4 | Increases excitability | Water deprivation | Body fluid homeostasis | Nedungadi 2014 |
| Glutamatergic MnPO neurons (m) | 1,5,7; PCR only | Increase excitability | Histamine | Thermoregulation | Tabarean 2012 |
| Glucose-excited neurons in MBH (m) | 3 | Increases excitability | Glucose | Energy homeostasis | Chretien 2017 |
| PMV neurons (m) | Putative, pharmacology only | Increases excitability | Leptin | Reproduction | Williams 2011 |
| GABAergic neurons in LH (m) | Putative, pharmacology only | Increases excitability results in MCH neuron inhibition | TRH | Anorexic and arousal actions | Zhang 2012 |
ARH, arcuate nucleus; GnRH, gonadotropin- releasing hormone; LH, lateral hypothalamus ; MBH, mediobasal hypothalamus ; MCH, melanin-concentrating hormone; MnPO, median preoptic nucleus; PCR, polymerase chain reaction ; PMV, ventral premammillary nucleus ; POMC, pro-opiomelanocortin; TRH, thyrotropin-releasing hormone. (m), mouse; (r), rat; (g), guinea pig.