Table 1.

Selected microRNAs involved in the regulation endothelial cell functions

Function	miRNA	Target	Reference
Regulation of vascular development, growth, and differentiation
	miR-126	Spredl	[44–49]
		PIK3R2/p85-b
	miR-149	Fgfrl	[32]
	miR-149*	Gpcl
	miR-218	Robo 1	[50–52]
		Robo2
		Glce
	miR-17~92	Elkl	[33■,53–55]
		Itga5
		Jakl
		Fzd4
	miR-23–24–27	Sprouty2	[56–59]
		Sema6A
		GATA2
		PAK4
	miR-132	p120RasGAP	[27]
	miR-221/222	STAT5A	[30]
	miR-150	c-Myb	[60]
	miR-210	Efna3	[61,62]
		Ptplb
		Dapkl
		Ctgf
	miR-424	Cul2	[63]
	miR-217	Sirtl	[64]
	miR-146	Nox4	[65]
	miR-216a	Becnl	[66]
Regulation of barrier function
	miR-125	Cadh5	[67]
	miR-147b	Adaml5	[68]
Regulation of vascular tone
	miR-155	eNOS	[69]
	miR-133a	Gchl	[70■■]
	miR-125a/b	Et-l	[71]
Control of leukocyte trafficking and inflammation
	miR-31	E-sele	[72]
	miR-17–3p	Icaml	[72]
	miR-126	Vcaml	[73]
	miR-181b	Kpna4	[74]
	miR-10a	Map3k7	[75,76,77■]
		βTRC
		IRAK4
	miR-146a/b	TRAF6	[78]
		IRAKl
		HuR
	Let-7g/a/b	Loxl	[79]
	miR-365	Bcl2	[80]
	miR-150	c-Myb	[60]

ADAM, disintegrin and metalloproteinase domain-containing protein; ADAM15, a disintegrin and metalloproteinase15; c-Myb, c- myeloblastosis transcription activator factor; Cul2, cullin 2; E-sele, E-selectin; GCH, GTP cyclohydrolase 1; HuR, human antigen R; Icam1, intracellular adhesion molecule1; Glce, glucuronyl C5-epimerase; Lox, lectin-like oxidized low-density lipoprotein receptor; miRNA, microRNA; PIK3R2, phosphoinositol-3 kinase regulatory subunit 2; Robo, roundabout receptors; Sema6A, semaphorin-6A; Sirt1; silent information regulator 1; Spred1, sprouty-related protein1, STAT, signal transducer and activator of transcription.

^*Passenger strand.