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. 2018 Oct 8;8:14906. doi: 10.1038/s41598-018-33279-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of Monosomy 14. (A) Principle Component Analysis shows separation between aneuploid and normal embryo samples, (B) Bar plot displaying the number of genes differentially expressed genes per chromosome, with the red and blue coloring indicating up and down regulation respectively, (C) Volcano plot displaying the significant genes color coded by red and green, indicating thresholds of adjusted p-value less than 0.05 and greater than log2 fold-change of 2, (D) Top gene ontology terms, significantly enriched in genes that are differentially expressed between monosomic and normal embryo samples.