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. 2018 Oct 8;8:14975. doi: 10.1038/s41598-018-33207-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of NCC^Dlx5 mice. (A) Strategy for conditional expression of Dlx5 from the Rosa26 locus and generation of NCC^Dlx5 mice. Probes for genotyping are indicated as 5′- and 3′- probes. E, EcoRI. (B) Comparison of Dlx5 mRNA levels in the maxillary arch (Mx), mandibular arch (Md) and PA2 of control and NCC^Dlx5 E10.5 embryo. Messenger RNA levels were estimated by qRT-PCR. The values showed on the graph were mean ± SD of 5 duplicated samples. Statistics: Mann-Whitney U test using R-software (version 3.1.3). *p < 0.01. (C,C’) Whole mount in situ hybridization for Dlx5 on control and NCC^Dlx5 E9.5 mice. Black arrows: areas of ectopic Dlx5 expression.