Figure 2.

External appearances of NCC^Dlx5 and NCC^∆Dlx5/6 mouse heads at E18.5. Craniofacial appearance of control (A-A”’), NCC^Dlx5 (B-B”’) and NCC^∆Dlx5/6 (C-D’) mice. NCC^Dlx5 mice have open eyelids (oe), a shortened snout (red arrowhead in B), misaligned vibrissae (open circles in A”, B”) and an open palate (op in B”’) with no sign of palatine rugae (pr in A”’). NCC^∆Dlx5/6 mouse heads present a severe mandibular retrognathism (red arrows in D, D’) with vibrissae well-aligned in the upper jaw, but also appearing ectopically in the lower jaw (open circles in C’, D’). The external ear (black arrow in C-D’) was severely hypomorphic in NCC^∆Dlx5/6 mice.