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. 2018 Oct 8;8:14914. doi: 10.1038/s41598-018-33267-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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P. gingivalis infection induces an inflammatory and pro-apoptotic cell death response in MT correlated to increased gene expression. (A–F) Gene expression of inflammatory and pro-apoptotic cell death response related genes: TNF-α, IL-6, IL-8, Bax-1, Bcl-2 and Apaf-1 in MT; monolayer cell culture of ECs and FBs infected with P. gingivalis at MOI 100 for 24 h; (G,H) Gene expression of integrin β1 and collagen IV. *Differences between infected or stimulated MT vs control (p < 0.05). ⁺Differences between infected or stimulated ECs vs control (p < 0.05). ^#Differences between infected or stimulated FBs vs control (p < 0.05).