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. 2018 Oct 8;8:14940. doi: 10.1038/s41598-018-33307-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GM-CSF administration increases functionally suppressive Tregs in peripheral lymphoid organs. GM-CSF was administered to C57BL/6 mice daily for 4 days (n = 3). (A) Representative dot plots of percent Tregs within various tissues of untreated and GM-CSF treated mice. (B) Bar graphs showing the percent Foxp3⁺ Tregs in indicated tissues from untreated and GM-CSF treated mice. Values are expressed as means ± SEM (n = 3; *p < 0.05, **p < 0.01). (C) Representative dot plot of percent Tregs with Ki67 expression from the spleen of untreated and GM-CSF treated mice. (D) Summary bar graphs for data shown in C Values are expressed as means ± SEM (n = 3; **p < 0.01). (E) Treg suppression analysis was performed on Tregs isolated from the spleens of untreated and GM-CSF mice. Representative histograms are shown. (F) Percent suppression was determined at each ratio of Tregs/Teff. Values are expressed as means ± SEM (n = 3; n.s. = not significant).