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. 2018 Oct 8;8:14937. doi: 10.1038/s41598-018-32923-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normalized dense volume and percent volumetric density measures as functions of age at the time of mammography, showing a smoothed Lowess curve. The normalized dense volume in cm³ and volumetric density in percentage measurements are shown as a Lowess curve both ungrouped and grouped by density grade. (a) The Lowess curve of the mean normalized percent volumetric density measurements and ages of all participants. (b) The Lowess curve of the mean of the normalized percent volumetric density measurement and age grouped by density grade. (c) The Lowess curve of the mean normalized dense volume measurement and age for all participants. (d) The Lowess curve of the mean normalized dense volume measurement and age grouped by density grade. All breast density grades were estimated in VDG by Volpara^TM. DV: volumetric density, VPD: percent volumetric density.