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. 2018 Oct 8;8:14967. doi: 10.1038/s41598-018-33402-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the effects of unilateral or bilateral TMNS on hypertension. (A–C) Changes in systolic blood pressure (BP) (A), diastolic BP (B) and HR (C) following the application of unilateral or bilateral TMNS. The data for bilateral TMNS shown in (A–C) are duplicated from the 10-Hz group shown in Fig. 1 according to recommendations of the IRB. The application of unilateral (left hand) or bilateral TMNS at a frequency of 10 Hz significantly decreased systolic BP compared to the values recorded before TMNS. A significant difference was not observed between the two groups (unilateral vs. bilateral). *p < 0.05 vs. the values obtained before TMNS (Time 0).