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. 2018 Oct 8;8:14967. doi: 10.1038/s41598-018-33402-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of electrical stimulation of the skin over the median or ulnar nerve on hypertension. (A) Experimental scheme. Location of electrodes for stimulation of the median nerve (Median site #1 and #2) or ulnar nerve (Ulnar site) sites and measurement of BP and HR. (B–D) Changes in systolic BP (B), diastolic BP (C) and HR (D) following electrical stimulation (10 Hz) of the skin innervating the median or ulnar nerve on the left hand. Decreases in systolic BP were more profound following the stimulation of the median nerve sites (Median site #1 & #2) than the stimulation of the ulnar nerve site (Ulnar site; A). Electrical stimulation of the palm side of the thumb (Median site #2) also tended to decrease diastolic BP and HR. *p < 0.05 vs. the value obtained before TMNS (Time 0). ^#p < 0.05 vs. the Ulnar site.