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. 2018 Oct 8;8:14967. doi: 10.1038/s41598-018-33402-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of a median nerve A-fiber block (AFB) on TMNS-induced antihypertensive effects. (A–C) AFB of the median nerve induced by compression in 6 subjects. Compression over the median nerve was performed with a 1.5-kg weight (A), and mechanical (B) and thermal sensitivities (C) were evaluated using von Frey filaments and warm water (57 °C), respectively. Mechanical thresholds were increased slowly, reaching a log value of 3.61 at 80 min after compression, whereas the thermal sensitivity in response to the 57 °C water was not changed after compression for up to 120 min. (D–F) Effect of the median nerve AFB on TMNS-induced antihypertensive effects on hypertensive subjects (n = 5). Changes in systolic BP (D), diastolic BP (E) and HR (F) following the application of TMNS (unilateral, 10 Hz) to the left hand subjected to 80 min of compression to establish a median nerve AFB. *p < 0.05 vs. the values obtained before TMNS.