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. 2018 Oct 8;8:14916. doi: 10.1038/s41598-018-33092-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compositions of microbiota in mice cecum on (a) phylum level and (b) genus level in all experimental groups and comparisons of relative abundance (percentage of sequences) of the (c) main bacterial phyla and (d) main bacterial genera. Calculation was based on average relative abundance of main bacterial communities. In (c) and (d), asterisk indicates difference within same treatment (MC vs. QC, MDSS vs. QDSS), ^*Indicates significant difference with P < 0.05, ^**Indicates P < 0.01 and ^***Indicates P < 0.001; ^#Represents a significant difference between same diet with different treatment (MC vs. MDSS, QC vs. QDSS), ^#Indicates significant difference with P < 0.05, ^##Indicates P < 0.01 and ^###Indicates P < 0.001. NS indicates lack of statistically significant difference.