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. 2018 Oct 8;8:14916. doi: 10.1038/s41598-018-33092-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LEfSE was used to identify the representative taxa in different groups. Output showing effect size of significantly enriched taxa in each group when perform comparison between (a) MC and MDSS; (c) QC and QDSS. Taxonomic cladogram obtained using LEfSe analysis of the 16S sequences from (b) MC vs. MDSS and (d) QC vs. QDSS. The differential abundant taxa are presented with designated colors using LEfSe method, Schemes follow the same formatting. The taxa from are colored in blue and orange, respectively. The taxa with nonsignificant changes between the non-DSS and DSS treated mice are colored in yellow. Each small circle’s diameter represents the taxon abundance.