Table 1.
Average Leukemia Risk Index (LRI) and Inflammatory Reaction Index (IRI) in ATL and HAM/TSP patients.
| Categories | No. of samples | Average IRI | SD of IRI | P value (IRI)* | Average LRI | SD of LRI | P value (LRI)* |
|---|---|---|---|---|---|---|---|
| Healthy PBMC | 20 | 0.4 | 0.28 | — | 2.33 | 1.25 | — |
| Low risk AC | 32 | 0.83 | 0.67 | 0.003 | 2.6 | 0.98 | 0.189 |
| Medium risk AC | 23 | 0.91 | 0.71 | 0.006 | 8.15 | 2.47 | <0.001 |
| High risk AC | 6 | 0.72 | 0.41 | 0.058 | 15.71 | 2.3 | <0.001 |
| smoldering ATL | 7 | 1.08 | 0.61 | 0.034 | 20.41 | 11.48 | 0.008 |
| chronic ATL | 21 | 1.13 | 1.01 | 0.002 | 45.08 | 17.47 | <0.001 |
| acute ATL | 4 | 3.58 | 2.68 | 0.132 | 60.97 | 16.58 | 0.009 |
| HAM/TSP | 10 | 7.86 | 1.81 | <0.001 | 3.73 | 2.33 | 0.131 |
Inflammatory Reaction Index (IRI) = 0.0001X (LL) + 0.5X (UL).
Leukemia Risk Index (LRI) = 0.0001X (LL) + 0.5X (LR) + (UR).
LRI (Low risk AC) < 4.5, 4.5 ≦ LRI (Midium risk AC) ≦ 13.0, 13.0 < LRI (High risk AC).
LL: Lower Left, UL: Upper Left, UR: Upper Right and LR: Lower Right of Quadrant in FCM profile.
AC: Asymptomatic HTLV-I carrier.
*P < 0.05 was regarded as statistical significant between Healthy PBMC and indicated category.