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. 2018 Oct 8;9(10):196. doi: 10.1038/s41424-018-0058-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The presence of GOAT by immunohistochemistry using a specific antibody was determined in a subset of samples, which included tumor and non-tumor regions from patients diagnosed with GEP-NETs. a Representative images of the IHC analysis of GOAT enzyme in a GEP-NET sample compared with the non-tumor adjacent tissue. b Absolute number of cases according to the intensity of GOAT IHC staining (0, 1 + , 2 + , 3 + ). c The graph indicates the percentage of tumor samples according to the intensity of GOAT expression by IHC, 0 and 1 + have been grouped as low expression while 2 + and 3 + have been grouped as high intensity by IHC. d Representative images of different GOAT staining in GEP-NETs. In the analysis, 0, 1 + , 2 + , 3 + stand for absent, low, moderate, and high intensities of the tumor region staining compared to the adjacent region with non-tumor tissue (3D1, 3D2, 3D3, 3D4, respectively). This analysis revealed that GOAT was present in the vast majority of tumor cells compared with non-tumor adjacent tissue, with different grades of staining. e Correlation between the absolute mRNA expression of GOAT determined by qPCR in GEP-NETs samples (values are adjusted by 18S expression) and the intensity of GOAT staining