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. 2018 Oct 8;8:14908. doi: 10.1038/s41598-018-33213-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tip55 homozygous knockout mice die at or before embryonic day 11.5. (A) Genotypes of embryos recovered at indicated stages of development or at birth. (B) Representative images of wild type (Tip55^+/+) and knockout (Tip55^Δ/Δ) embryos at stages indicated. Different magnifications as indicated (lower right) were required to image embryos at each stage, owing to differences in size. (C) Whole-mount in situ hybridization of Tip55 transcript. Shown are wild type E8.5-E9.0 mouse embryos hybridized with antisense or sense (as a negative control) in situ hybridization probes corresponding to the region of intron 11 retained in the Tip55 transcript but not found in all other Kat5 isoforms.