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. 2018 Oct 8;8:14908. doi: 10.1038/s41598-018-33213-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tip55 loss leads to defects in heart and neural tube. (A) Hematoxylin and Eosin (H&E) stained E8.5 embryo sections of Tip55^+/+ and Tip55^Δ/Δ embryos, shown at multiple magnifications to reveal overall morphology (4X) or focus on heart (20X, above) and neural tube (20X, below). (B) Immunohistochemistry staining of cleaved caspase 3 (CC3) or Histone H3 phosphorylated on serine 10 (H3S10P) on E8.5 sections of Tip55^+/+ and Tip55^Δ/Δ embryos. Examples of positively staining cells denoted with arrowheads. (C,D) Quantification of cells staining positively for each H3S10P and CC3 in heart (C) and neural tube (D). N = 3 embryo sections were used. P-values were calculated using a two-sided t-test.