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. 2018 Oct 8;8:14958. doi: 10.1038/s41598-018-33352-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Beauvericin inhibits the expression of melanogenesis-related genes. (A) B16F10 cells were incubated with the indicated concentrations of beauvericin for 24 h. mRNA levels of melanogenesis-related genes MITF, tyrosinase, TRP-1, and TRP-2 were determined by real-time PCR. The results were expressed relative to untreated cells after normalization against the GAPDH level. Results were confirmed from at least three independent experiments and values represent the means ± SEM. *P < 0.05 vs. untreated control. P-values were obtained by Student’s t-test. (B) B16F10 cells were incubated with the indicated concentrations of beauvericin for 24 h. The protein levels of MITF, tyrosinase, TRP-1, and TRP-2 were determined by Western blot analysis. Equivalent amounts of protein were analyzed. Results were confirmed from at least three independent experiments and values represent the means ± SEM. P-values were obtained by the one-way ANOVA. *P < 0.05 vs. untreated control. BEA, beauvericin.