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. 2018 Oct 8;8:14931. doi: 10.1038/s41598-018-33383-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene Regulatory Network (GRN) of differentially expressed genes in the mutant strains grown in glucose, sugarcane, and glycerol. (A) GRN of 402 differentially expressed genes in the Δtmk1 compared to the QM6a (Δtmk1/QM6a) in the presence of glucose, glycerol, and sugarcane bagasse. Genes are represented as nodes (circles), and interactions are represented as edges (red lines: upregulated interactions, green lines: downregulated interactions), connecting the nodes: 382 interactions, (B) GRN of 2575 differentially expressed genes in the Δtmk2 compared to the QM6a (Δtmk2/QM6a) in the presence of glucose, glycerol, and sugarcane bagasse. Genes are represented as nodes (shown as circles), and interactions are represented as edges (red lines: upregulated interactions, green lines: downregulated interactions), connecting the nodes: 1980 interactions.