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. 2018 Oct 2;9:2256. doi: 10.3389/fimmu.2018.02256

Figure 1.

Figure 1

Genetic interactions between SP genes and associations with CF (A). Genetic association of SFTPB and SFTPC with CF by single SNP, and intragenic and intergenic SNP-SNP interactions between SFTPB and SFTPC, and with SFTPA1 and SFTPA2. On the left SNPs of the surfactant genes SFTPA1 and SFTPA2 encoding the hydrophilic surfactant proteins, SP-A1 and SP-A2 and on the right SNPs of the surfactant genes SFTPB and SFTPC, encoding the hydrophobic proteins, SP-B and SP-C, are shown (B). Genetic association of SFTPB and SFTPC with CF by single SNP, and intragenic and intergenic SNP-SNP interactions between SFTPB and SFTPC, and with SFTPD. On the left SNPs of SFTPD and on the right SNPs of SFTPB and SFTPC are shown: In Figure, the star depicts a single SNP association with CF, the black dash line depicts intragenic interactions associated with CF, and the black solid line depicts intergenic interactions associated with CF.