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. 2018 Oct 2;9:2256. doi: 10.3389/fimmu.2018.02256

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Copyright © 2018 Lin, Thorenoor, Wu, DiAngelo, Ye, Thomas, Liao, Lin, Warren and Floros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of SNP interactions between genes encoding the surfactant proteins. The cartoon in this figure depicts the observed associations and reveals the following: (a) No association between SFTPD and SFTPA1 or SFTPA2. (b) Out of the 34 intergenic interactions, 28 are between genes encoding the hydrophobic and the hydrophilic surfactant proteins. Only four are between genes (SFTPB and SFTPC) encoding the hydrophobic surfactant proteins and two are between genes (SFTPA1 and SFTPA2) encoding the hydrophilic SP-A1 and SP-A2. (c) SFTPC has the highest number of interactions with SFTPA1 (n = 8), while SFTPB has the highest number of interactions with SFTPD (n = 7). (d) SFTPB has a total of 14 intergenic interactions with genes encoding hydrophilic proteins, seven with SFTPD, four with SFTPA2, and three with SFTPA1. SFTPC also has 14 intergenic interactions, eight with SFTPA1, three with SFTPA2 and only 3 with SFTPD. (e) SFTPA1 has two intergenic interactions with SFTPA2, as well as intragenic interactions. (f) SFTPB is the only other gene (other than SFTPA1) that has an intragenic interaction. (g) Only SFTPB and SFTPC have each a single SNP association with CF.