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. 2018 Oct 2;9:2256. doi: 10.3389/fimmu.2018.02256

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Copyright © 2018 Lin, Thorenoor, Wu, DiAngelo, Ye, Thomas, Liao, Lin, Warren and Floros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions in mild and moderate/severe CF subgroups with p-value < 0.01; these interactions were significant in the entire CF group after Bonferroni correction. Mild CF: Significant interactions between SFTPA1, SFTPA2, SFTPB, and SFTPD are shown with black arrows. Green box indicates the only SNP that remained significant after Bonferroni correction. Star (*) indicates that this SNP is significant at p < 0.03 by itself. Moderate/severe CF: Red arrow shows the only significant interaction at p < 0.01 that is also significant in the entire CF groups after Bonferroni correction. No significant interactions that include SNPs of the SFTPC are observed in either severity group.