Table 4.
Genetic association of surfactant protein genes SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with CF by intergenic interactions.
| Interaction # | SNP #1 | SNP #2 | Interaction type | x2 | p-value | ||
|---|---|---|---|---|---|---|---|
| Gene name | SNP ID | Gene name | SNP ID | ||||
| 1 | SFTPA1 | rs1136450 | SFTPA2 | rs1059046 | a1d2 | 3.1699 | 0.0485 |
| 2 | SFTPA1 | rs4253527 | SFTPA2 | rs1059046 | a1 | 5.1800 | 0.0233 |
| 3 | SFTPA1 | rs1136450 | SFTPB | rs7316 | d1d2 | 2.7135 | 0.0213 |
| 4 | SFTPA1 | rs1059057 | SFTPB | rs7316 | d2 | 3.1499 | 0.0332 |
| 5 | SFTPA1 | rs4253527 | SFTPB | rs7316 | d2 | 3.2619 | 0.0303 |
| 6 | SFTPA1 | rs1059047 | SFTPC | rs1124 | d2 | 5.6874 | 0.0053 |
| a1d2 | 7.8947 | 0.0014 | |||||
| d1d2 | 4.6019 | 0.0021 | |||||
| 7 | SFTPA1 | rs1136451 | SFTPC | rs1124 | d2 | 6.1400 | 0.0007 |
| a1d2 | 6.5633 | 0.0449 | |||||
| d1d2 | 3.4875 | 0.0027 | |||||
| 8 | SFTPA1 | rs1059057 | SFTPC | rs1124 | d2 | 6.1715 | 0.0007 |
| d1 | 4.4217 | 0.0104 | |||||
| a1d2 | 8.4508 | 0.0146 | |||||
| d1d2 | 5.3013 | 0.0293 | |||||
| 9 | SFTPA1 | rs1059047 | SFTPC | rs4715 | a1d2 | 3.1655 | 0.0487 |
| 10 | SFTPA1 | rs1136450 | SFTPC | rs4715 | a1d2 | 3.5583 | 0.0182 |
| 11 | SFTPA1 | rs1136450 | SFTPC | rs1124 | a1d2 | 4.1079 | 0.0187 |
| 12 | SFTPA1 | rs1136451 | SFTPC | rs4715 | d2 | 3.2576 | 0.0328 |
| a1d2 | 4.8166 | 0.0236 | |||||
| d1d2 | 2.6958 | 0.0218 | |||||
| 13 | SFTPA1 | rs4253527 | SFTPC | rs1124 | d2 | 2.2285 | 0.0404 |
| 14 | SFTPA2 | rs1059046 | SFTPB | rs1130866 | a1d2 | 3.4707 | 0.0390 |
| 15 | SFTPA2 | rs1965707 | SFTPB | rs2077079 | d1d2 | 4.1099 | 0.0043 |
| 16 | SFTPA2 | rs1965708 | SFTPB | rs2077079 | d1d2 | 2.4405 | 0.0262 |
| 17 | SFTPA2 | rs1965708 | SFTPB | rs7316 | d2 | 2.4172 | 0.0331 |
| 18 | SFTPA2 | rs17886395 | SFTPC | rs1124 | a1d2 | 6.4974 | 0.0038 |
| d2 | 3.6608 | 0.0257 | |||||
| 19 | SFTPA2 | rs1059046 | SFTPC | rs4715 | a1d2 | 4.1992 | 0.0227 |
| 20 | SFTPA2 | rs1059046 | SFTPC | rs1124 | d2 | 2.9051 | 0.0471 |
| a1d2 | 4.1161 | 0.0221 | |||||
| 21 | SFTPB | rs2077079 | SFTPC | rs1124 | a1d2 | 3.5371 | 0.0344 |
| 22 | SFTPB | rs1130866 | SFTPC | rs4715 | d1a2 | 4.6271 | 0.0121 |
| 23 | SFTPB | rs1130866 | SFTPC | rs1124 | d2 | 3.9303 | 0.0207 |
| 24 | SFTPB | rs7316 | SFTPC | rs1124 | d2 | 2.4947 | 0.0303 |
| a1d2 | 2.4947 | 0.0392 | |||||
| 25 | SFTPB | rs2077079 | SFTPD | rs2243639 | a1a2 | 8.3123 | 0.0058 |
| 26 | SFTPB | rs3024798 | SFTPD | rs2243639 | a1a2 | 7.0808 | 0.0058 |
| a2 | 3.5108 | 0.0311 | |||||
| 27 | SFTPB | rs7316 | SFTPD | rs2243639 | d1d2 | 2.6436 | 0.0094 |
| d2 | 2.0495 | 0.0494 | |||||
| 28 | SFTPB | rs2077079 | SFTPD | rs721917 | a1a2 | 5.4000 | 0.0108 |
| d1d2 | 2.6197 | 0.0306 | |||||
| 29 | SFTPB | rs3024798 | SFTPD | rs721917 | a1a2 | 4.4454 | 0.0398 |
| d1d2 | 2.5095 | 0.0242 | |||||
| d1a2 | 4.0265 | 0.0151 | |||||
| 30 | SFTPB | rs1130866 | SFTPD | rs721917 | d1a2 | 3.4263 | 0.0193 |
| 31 | SFTPB | rs1130866 | SFTPD | rs2243639 | d2 | 3.1616 | 0.0382 |
| d1a2 | 3.0764 | 0.0347 | |||||
| 32 | SFTPC | rs4715 | SFTPD | rs721917 | d1a2 | 5.8333 | 0.0049 |
| 33 | SFTPC | rs1124 | SFTPD | rs721917 | d1 | 5.0904 | 0.0075 |
| d1a2 | 4.5151 | 0.0099 | |||||
| 34 | SFTPC | rs1124 | SFTPD | rs2243639 | d1 | 4.4393 | 0.0247 |
A total of 34 interactions of the 5 surfactant protein genes are associated with CF. Interaction type: a - additive, d - dominant, ad - additive x dominant, da - dominant x additive, and dd - dominant x dominant between the two SNPs.
Number 1 and 2 in interaction type column; represent SNP1 and SNP2.
The a1 stands for a additive effect for SNP1 and a2 stands for additive effect for SNP2.
The d1 stands for a dominant effect for SNP1, and d2 stands for a dominant effect for SNP2.
The a1d2 stands for the interaction type is additive effect for SNP1 and dominant effect for SNP2.
The d1a2 stands for the interaction type is dominant effect for SNP1 and additive effect for SNP2.