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. 2018 Oct 2;11:362. doi: 10.3389/fnmol.2018.00362

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Copyright © 2018 Zhu, Cheng, Wang, Muhammad, Liu, Zhu, Shao, Zhang, Yan, He, Xu, Yu, Qian, Lu, Zhang, Zhang, Xiong, Gao, Xu and Chai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Progressive OHC loss was observed in Arhgef6 knockdown mice. (A–E) Confocal images of whole-mount cochleae from P14/P30/P60/P90 Arhgef6 knockdown mice and P90 wildtype mice stained with Myosin VIIa (red) and DAPI (white). Scale bar: 20 μm. (F–H) The percentage of OHCs lost per 200 μm of the cochlea in Arhgef6 knockdown mice and wildtype mice at P14/P30/P60/P90 in the apex, middle, and base of the cochlea. Data are presented as the mean ± SEM, n = 10/genotype. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.