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. 2018 Oct 2;11:362. doi: 10.3389/fnmol.2018.00362

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Copyright © 2018 Zhu, Cheng, Wang, Muhammad, Liu, Zhu, Shao, Zhang, Yan, He, Xu, Yu, Qian, Lu, Zhang, Zhang, Xiong, Gao, Xu and Chai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of ARHGEF6 resulted in a significant decrease in PAK1. (A) q-PCR results of the relative levels of PAK1, PAK2, PAK3, LIMK1, LIMK2, Cofilin1, and Cofilin2 in the cochleae of Arhgef6 knockdown mice compared to wildtype mice at P3. Western blot analysis of PAK1 and p-PAK in the cochleae of Arhgef6 knockdown mice and wildtype mice at P3. PAK1 protein was mildly decreased in Arhgef6 knockdown cochleae (B), and p-PAK was significantly decreased in the cochleae of Arhgef6 knockdown mice (C). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.