FIGURE 4.

Running restored the number of newborn neurons and neuronal differentiation in the hippocampal dentate gyrus in diabetic mice. (A) STZ administration significantly suppressed number of immature neurons in hippocampal DG, ^∗P < 0.05 vs. STZ runners, ^∗∗P < 0.005 vs. control runners, ^∗∗P < 0.005 vs. STZ non-runners. (B) Running significantly increased neuronal differentiation estimated by the co-ratio of BrdU and DCX labeling in both control, and STZ mice. ^∗∗P < 0.005 vs. STZ runners, ^∗P < 0.05 vs. control runners, ^∗∗P < 0.005 vs. STZ non-runners. (C) Representative images of DCX⁺ cells cells in the hippocampal DG (Scale bars, 100 μm in 100 ×, 10 μm in 400 × ). (D) Representative images of BrdU/DCX co-labeling.