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. 2018 Oct 2;9:1072. doi: 10.3389/fphar.2018.01072

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Copyright © 2018 Haider, Black, Parks, Foley, Wetmore, Andersen, Clewell, Mansouri and McMullen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of MetaCore pathways enriched by up and down-regulated genes of (A) actual gene expression classes for TG-GATEs genes in response to 100 μM 2,4-dinitrophenol and (B) predicted gene expression using combined surrogate genes and a consensus prediction of all 3 prediction models. All colored nodes are significant at an enrichment FDR < 0.005 with a minimum of five query elements found in category elements. Ontologic enrichment of genes were performed against the public MetaCore Ontology and the enrichment was visualized. We have found that the predicted Affymetrix genes has a very similar enrichment profile as the actual gene expression. Thirty-eight (38) out of sixty-one (61) significantly enriched categories (shown in green) were common between actual and predicted gene expression classes.