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. 2018 Oct 2;9:2316. doi: 10.3389/fmicb.2018.02316

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Copyright © 2018 Hu, He, Elsheikha, Zhang, Zou, Zhao, Cong and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG analysis of the differentially expressed miRNAs (P < 0.05) revealed significant enrichment in immune-related pathways. The top 20 enriched pathways of the differentially expressed miRNAs are presented for (A) “Acute vs. Uninfected,” (B) “Chronic vs. Uninfected” and (C) “Chronic vs. Acute.” The degree of KEGG enrichment was determined by the enrichment factor, q-value, and miRNA gene target number. The sizes and colors of the spots represent the number of predicted gene targets of the differentially expressed miRNAs (P < 0.05) and the q-value, respectively.