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. 2018 Oct 2;9:1119. doi: 10.3389/fphar.2018.01119

FIGURE 3.

FIGURE 3

Influence of the pre-treatment with morphine or amitriptyline on the anti-allodynic effect of mangiferin (100 mg/kg, 1 mL/kg, i.p., MG) or vehicle (DMSO 5%) 72 h after the ischemia/reperfusion-injury. Animals received (A) saline or morphine (0.3–3 mg/kg), (B) saline or amitriptyline (3–10 mg/kg). The effect of MG and the highest dose of agonist drug morphine were reversed by naloxone (1 mg/kg). Each column represents the reactivity time of 6–7 animals per group as mean ± SEM. ∗P < 0.05 represents the statistical difference between CPIP post-drug and CPIP pre-drug, while ⋅P < 0.05 represents the statistical difference between CPIP post-drugs in the presence or absence of MG, ≠P < 0.05 represents the statistical difference between CPIP post-groups treated with MG or highest dose of morphine in the presence or absence of naloxone, ϕP < 0.05 represents the statistical difference between treated groups regarding control vehicle (SS-DMSO).