Table 1.
Redox biomarkers in ipsilateral muscles of sham and CPIP rats treated with repeated oral doses of mangiferin (MG), prednisone (P), or vehicle.
| Group | Dose | MDA (μM/mg Pr) | CG (nM/mg Pr) | NO (μM/mg Pr) | GSH (μM/mg Pr) | SOD (U/L/mg Pr) |
|---|---|---|---|---|---|---|
| Sham-CPIP | 10 mL/kg | 2.10 ± 0.15 | 0.71 ± 0.02 | 14.26 ± 0.74 | 108.20 ± 5.36 | 26.33 ± 0.85 |
| CPIP-vehicle | 10 mL/kg | 5.53 ± 0.32c | 1.96 ± 0.05c | 35.26 ± 1.38c | 61.18 ± 2.38c | 69.72 ± 1.55c |
| CPIP-P5 | 5 mg/kg | 3.43 ± 0.30b | 1.19 ± 0.04a | 17.61 ± 0.51a | 84.52 ± 3.03b | 40.09 ± 2.93a |
| CPIP-MG100 | 100 mg/kg | 3.20 ± 0.11a | 0.94 ± 0.04a | 24.37 ± 1.28a | 81.97 ± 1.91a | 38.91 ± 2.03a |
Data are presented as mean ± SEM of n = 5–6 per group. ap ≤ 0.001, bp ≤ 0.01 represent the statistical difference between treated groups and control (CPIP – vehicle group), and cp ≤ 0.001 represent the statistical difference between treated groups and sham – CPIP group. CMC 0.05% was used as the vehicle by the oral route. CPIP, chronic post-ischemia pain; CG, carbonyl protein groups concentration; GSH, reduced glutathione; MDA, malondialdehyde; NO, nitric oxide; Pr, protein; SOD, superoxide dismutase.