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. 2018 Oct 2;9:2196. doi: 10.3389/fimmu.2018.02196

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Copyright © 2018 Takeuchi, Ozawa, Kanda, Kozai, Ohigashi, Kurosawa, Rahman, Kawamura, Shichida, Umemoto, Miyasaka, Ludewig, Takahama, Nagasawa and Katakai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cells control the optimal development of the medulla and DCP in mouse LNs. (A) Development of the medulla was attenuated in the LNs of μMT mice, which was restored with bone marrow transfer. Vertical sections of inguinal LNs isolated from wild type B6, μMT mice, or μMT mice reconstituted with wild type bone marrow (wtBM) were stained with antibodies against LYVE-1, desmin, and B220. Representative images are shown. Higher magnification view of the boxed region is shown in the right panel. (B) Proportion of medulla in the LNs (bars: mean; *p < 0.005). (C) The DCP was attenuated in Cxcl12-EGFP/μMT mice LNs, which was restored with bone marrow transfer. Vertical sections of brachial LNs isolated from Cxcl12-EGFP, Cxcl12-EGFP/μMT mice, or Cxcl12-EGFP/μMT mice reconstituted with wild type bone marrow (wtBM) were stained with antibodies against LYVE-1, desmin, and B220. Higher magnification view of the boxed region is shown in the right panel. (D) Proportion of DCP in the LNs (bars: mean; *p < 0.005, **p < 0.0001).