Table VI.
Frequency of four CYP2D6 non-functional alleles in different populations.
| Allele frequency (%) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Population | Year | N | Patient Status | *3 | *4 | *10 | *17 | Refs. |
| Iranian | 2018 | 84 | BCP | Nd | 52.4 | 26.2 | 3.6 | Present study |
| Iranian | 2009 | 100 | HP | – | 12.5 | 9.0 | Nd | (26) |
| Iranian | 2011 | 100 | HP | 0.5 | 9.0 | – | – | (46) |
| Iranian | 2015 | 101 | BCP | – | 36.6 | – | – | (37) |
| Japanese | 2000 | 412 | HP | – | 0.2 | 38.1 | – | (22) |
| Chinese | 2009 | 100 | HP | – | 1.0 | 49.0 | – | (21) |
| Spanish | 2006 | 105 | HP | 0.95 | 13.8 | – | – | (39) |
| Brazilian | 2016 | 80 | BCP | – | 13.75 | 21.25 | 10.0 | (40) |
| Pakistani | 2016 | 232 | BCP | – | – | 7.0 | – | (35) |
| South-Indian | 2006 | 447 | HP | Nd | 7.3 | 10.2 | Nd | (36) |
| Malaysian Indian | 2016 | 80 | BCP | – | 28.6 | 21.4 | – | (18) |
| Malaysian Malay | 2016 | 80 | BCP | – | 2.9 | 54.8 | – | (18) |
| Malaysian Chinese | 2016 | 80 | BCP | – | Nd | 71.4 | – | (18) |
| Malaysian Malay | 2001 | 107 | HP | – | 2.8 | 49.5 | 0.5 | (42) |
| Korean | 2006 | 400 | HP | – | – | 45.0 | – | (34) |
| Thai | 2012 | 67 | BCP | – | – | 51.0 | (23) | |
| Turkish | 2009 | 100 | HP | – | 28.0 | – | – | (38) |
| Turkish | 2005 | 140 | HP | 2.5 | 13.9 | – | – | (47) |
| Saudi Arabians | 1997 | 101 | HP | – | 3.5 | 3.0 | 3.0 | (20) |
| USA | 2006 | 158 | BCP | 0.013 | 0.161 | 0.035 | – | (41) |
Nd, not detected; HP, healthy population; BCP, breast cancer population.