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. 2018 Oct 2;5:281. doi: 10.3389/fmed.2018.00281

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Copyright © 2018 Chinnaraj, Planer and Pozzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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X-ray crystal structures of closed and open conformations of prothrombin. (A) Structure of the prothrombin mutant S101C/A470C (proTCC) solved at 4.0Å resolution (PDB ID: 6C2W) (15). (B) Structure of the prothrombin mutant Δ154–167 (proTΔ154–167) solved at 2.2Å resolution (PDB ID: 5EDM) (33). Key residues Trp547 in the protease domain and Tyr93 in the kringle-1 are shown in magenta.